Plenary Lecture Accorded by the LOTTE Foundation (Open Lecture for Citizenry)

August 25 (Thu) 13:00～14:00
「Modeling human psychiatric/neurological disorders using iPS cell technologies and transgenic non-human primates」
Speaker
　Hideyuki Okano (Dept Physiol, Keio Univ Sch Med)

Symposium Accorded by the LOTTE Foundation

August 25 (Thu) 14:10～16:10
「A new horizon for gene-targeting medical technologies」

• FS-1「The maturation of gene therapy: oral and general applications now and on the horizon」
  Bruce J. BAUM (Scientist Emeritus, Natl Inst Dent Craniofac Res)
• FS-2「Development of Therapeutic Modality for Fibrosis by Use of VA-liposome HSP47」
  Niitsu Y (Molecular Target Exploration Lab., Center for FMI, Hokkaido Univ)
• FS-3「Front-line of genetic engineering using genome editing technology」
  Sakuma T (Dept Math and Life Sci, Grad Sch Sci, Hiroshima Univ)

Symposium of JAOB

August 25 (Thu) 9:00～11:00
「Current status of basic research for tissue regeneration」

• KS-1「Epiprofin regulates dental epithelial stem cell fate to the ameloblast lineage and differentiation through its multiple functions」
  Yamada Y (Lab Cell Dev Biol, NIDCR, NIH)
• KS-2「Laminin active peptides conjugated matrices as a biomaterial for tissue engineering」
  Nomizu M (Dept Clin Biochem, Tokyo Univ Pharmacy Life Sci)
• KS-3「Senescence changes the extracellular matrix environment in adult neurogenesis」
  Arikawa-Hirasawa E (Res Inst for Dis of Old Age, Grad Sch Med, Juntendo Univ)
• KS-4「Regenerative approach of salivary gland targeting stem cells」
  Sakai T (Dept Oral-facial Disorders, Osaka Univ Grad Sch Dent)
• KS-5「SCFβ-TRCP E3 ubiquitin ligase promotes lipid synthesis in an mTORC-dependent manner」
  Inuzuka H (Center for Adv Stem Cell and Regenerative Res, Tohoku Univ)

Symposium of Science Council of Japan

August 25 (Thu) 9:00～11:00

• CS-1「Signal transduction between oral biology and clinical dental research」
  Yamaguchi A (Oral Health Sci Center, Tokyo Dent Coll)
• CS-2「Periodontal tissue regeneration with BDNF (brain-derived neurotrophic factor)」
  Kurihara H (Dept Periodont Med, Div Appl Life Sci, Inst Biomed Health Sci, Hiroshima Univ)
• CS-3「Costimulation Research -from bench to bedside and back to bench-」
  Azuma M (Tokyo Med Dent Univ, Grad Sch Med Dent Sci; Member, Science Council of Japan)
• CS-4「Future directions of clinical treatment of orofacial pain disorders: Any hope for feedback from basic research?」
  Yatani H (Dept Fixed Prosthodont, Osaka Univ Grad Sch Dent)
• CS-5「Orofacial pain its underlying mechanism and clinical relevance」
  Iwata K (Dept Physiol, Sch Dent, Nihon Univ)

Main symposium

Main symposium A

August 25 (Thu) 9:00～11:00

• MSA-1「In vivo imaging analyses for monitoring the intracellular signaling with biological functions: monitoring of Ca²⁺ responses in salivary acinar cells with salivary secretions and blood flow.」
  Tanimura A (Div Pharmacol, Sch Dent, Health Sci Univ Hokkaido)
• MSA-2「In vitro analysis of homeostatic mechanism of bone using two-photon microscopy」
  Hikita A (Dept Cartilage & Bone Regeneration, Grad Sch Med, The Univ Tokyo）
• MSA-3「Functional analyses of bone cells by integrative approaches of multimodal super resolution microscopy」
  Iimura T^{1, 2, 3, 4}
  (¹Ehime Univ, Proteo-Science Center (PROS)，²Ehime Univ, Advanced Research Support Center (ADRES)，³Ehime Univ, Grad Sch Med，⁴Ehime Univ Hosp, Artificial Joint Integrated Center)
• MSA-4「Electron microscopy of tissues, cells and molecules in hydrophilic environment」
  Sato C（Biomed-sps AIST）

Main symposium B

August 25 (Thu) 15:00～17:00

• MSB-1「Oral microecosystem -Listen to the silent majority-」
  Takahashi N (Div Oral Ecol Biochem, Dept Oral Biol, Tohoku Univ Grad Sch Dent)
• MSB-2「Scardovia wiggsiae and its potential role as a caries pathogen」
  Christine Kressirer (The Forsyth Institute, Cambridge, MA, USA)
• MSB-3「The strategy for oral biofilm -The best use of oral Veillonella-」
  Mashima I (Postdoctoral Fellow of JSPS, Dept Oral Microbiol, Sch Dent, Health Sci Univ Hokkaido)
• MSB-4「Polymicrobial Candida biofilms: friends and foe in the oral cavity」
  Gordon Ramage (Oral Sci Res Group, Glasgow Dent Sch, Sch Med, Dent Nursing, Univ Glasgow, UK)

Main symposium C

August 26 (Fri) 9:00～11:00

• MSC-1「Structure and function of maturation stage ameloblasts: An overview」
  Takano Y (Tokyo Med Dent Univ (Emeritus))
• MSC-2「The role of KLK4 and maturation-stage Ameloblasts」
  Yamakoshi Y (Dept Biochem Mol Biol, Sch Dent Med, Tsurumi Univ)
• MSC-3「Expression and function of TRP channel involved in enamel mineralization」
  Okabe K (Cell Physiol, Fukuoka Dent Coll)
• MSC-4「Function of V-ATPase for highly calcification during enamel maturation」
  Harada H (Dept Anat,Niigata Univ Grad Sch)
• MSC-5「Role of glucose metabolism in cell differentiation of maturation stage ameloblasts」
  Ida-Yonemochi H (Div Anat Cell Biol Hard Tissue, Niigata Univ Grad Sch Med Dent Sci)

Main symposium D

August 26 (Fri) 13:10～15:10

• MSD-1「Studies on molecular mechanisms underlying dementia induced by periodontal disease and masticatory dysfunction in mice.」
  Michikawa M (Dept Biochem, Nagoya City Univ Sch Med Sci)
• MSD-2「Modulation of higher brain function in association with food characteristics during growth period」
  Ono T (Orthodont Sci, Tokyo Med Dent Univ)
• MSD-3「Activating and inhibitory system in the peripheral–central neuronal networks of orofacial sensation」
  Kuramoto E (Dept Oral Anat & Cell Biol, Grad.Sch Med & Dent Sci, Kagoshima Univ)
• MSD-4「How human brains activate by tastes in the mouths? : From brain mapping to the network.」
  Tazuko K. Goto (Dept Oral and Maxillofac Radiol, Tokyo Dent Coll)

Satellite symposium

Satellite symposium 1

August 24 (Wed) 12:30～14:10

• SS1-1「How much has implant dentistry satisfied patients?」
  Toshitake Furusawa (Grad Sch Sci Engin, Yamagata Univ/ Furusawa Dental Clinic)
• SS1-2「New solution to oral implant for gingival integration」
  Kimitoshi Yagami (Dept Stomatol for Health Promotion, Grad Sch, Matsumoto Dent Univ)
• SS1-3「Application of CNTs to the surface treatment of titanium」
  Atsuro Yokoyama (Dept Oral Funct Prosthdont Hokkaido Univ Grad Sch Dent Med)
• SS1-4「The efficacy and limitation of hydroxyapatite coated implants」
  Ochi M (Health Sci Univ Hokkaido Sch Dent Div Fixed Prosthodont Oral Implantol)
• SS1-5「Fusion of Dentin Materials and Bone Inductive Surgery for Bone Regeneration」
  Masaru Murata (Oral and Maxillofac Surg, Health Sci Univ Hokkaido)
• SS1-6「Application of autologous platelet rich plasma (PRP) for hard and soft tissues reconstruction around the dental implants」
  Hajime Okudera (Tokyo Dental Plastic Society)
• SS1-7「Elucidation of the mechanism for the titanium-fixation in living bone: discovery of the implant proteins and its clinical application」
  Yoshinori Kuboki (Fac Earth Environ Sci, Hokkaido Univ)

Satellite symposium 2

August 24 (Wed) 12:30～14;10

• SS2-1「Three-dimensional ultrastructural analysis on hard tissue interface」
  Shingo Hirashima (Dept Anat, Kurume Univ sch Med)
• SS2-2「3-dimentional evaluation of dentinal caries using FIB/SEM tomography」
  Jiro Miura (Div Interdisci Dent. Osaka Univ Grad Sch Dent)
• SS2-3「The osteocyte network formation is influenced by the collagen-bundle formation」
  Mana Hashimoto (Dept Orhodont Okayama Univ Grad Sch Med Dent Pharm Sci)
• SS2-4「3D observation of the titanium implant and bone tissue interface」
  Noriyuki Nagaoka (ARCOCS, Okayama Univ Grad Sch Med Dent Pharm Sci)
• SS2-5「Morphological observation of bone formation around titanium implants using FIB-SEM in type 2 diabetic rats」
  Shin-ichiro Kawamoto (Dept Oral Maxillofac Prosthodont, Grad Sch Med Dent Sci, Kagoshima Univ)

Satellite symposium 3

August 24 (Wed) 12:30～14:10

• SS3-1「Overview (New concept for receptor-mediated signaling)」
  Akihiko Tanimura (Div. Pharmacol., Sch. Dent., Health Sci. Univ. Hokkaido)
• SS3-2「New strategy for acetylcholinesterase inhibitors in bone regenerative medicine」
  Tsuyoshi Sato (Dept Oral and Maxillofac Surg, Fac Med, Saitama Med Univ)
• SS3-3「α7 nicotinic acetylcholine receptor: a promising therapeutic target for osteoporosis」
  Makio Saeki (Niigata Univ Grad Sch Med Dent, Sci Div Dent Pharmacol)
• SS3-4「Neuropsychopharmacology of muscarinic acetylcholine receptors」
  Kazuhiro Takuma (Dept Pharmacol, Osaka Univ Grad Sch Dent)
• SS3-5「Involvement of serotonin and serotonin receptors in the migraine pathophysiology」
  Cui Y (Mol Dynamics Imaging Unit, RIKEN Center for Life Sci Technol)
• SS3-6「Cholinergic regulation of medium spiny neuron activity in the rat nucleus accumbens」
  Kobayashi M (Dept Pharmacol, Nihon Univ Sch Dent)

Satellite symposium 4

August 24 (Wed) 12:30～14:10

• SS4-1「Involvement of neuron-glial interaction in the trigeminal ganglion in neuropathic pain」
  Kaori Kaji (Dept Physiol, Nihon Univ Sch Dent, 2Dept Orthodont, Nihon Univ Sch Dent)
• SS4-2「Role of proteinases in dental enamel development」
  Masashi Shin (Div Cell Physiol, Fukuoka Dent Coll)
• SS4-3「Live cell fluorescence imaging for the prevention of oral diseases」
  Nishide S (Dept Cell Physiol, Hokkaido Univ Grad Sch Med)

Satellite symposium 5

August 24 (Wed) 12:30～14:10

• SS5-1「Distribution of blood vessels and nerves at palatine by the three-dimensional positional observation」
  Miwa Y (Dept Anat, Nippon Dent Univ)
• SS5-2「Microvascular architecture of the palatine mucosa」
  Toda I (Dept Anat, Osaka Dent Univ)
• SS5-3「Vascular structure and function of palatal microcirculation」
  Matsuo M (Div Dent Anat,Kanagawa Dent Univ Grad Sch Dent.)
• SS5-4「Lymphatic architecture of Suncus murinus (House Musk shrew) palatum」
  Ando Y (Div Func Mor, Dept Anat, Iwate Med Univ)

Satellite symposium 6

August 24 (Wed) 12:30～14:10

• SS6-1「Evaluation of temporal alteration of orthodontic pain」
  Adachi K (Meikai Univ Sch Dent, Div Pharmacol)
• SS6-2「Spatiotemporal properties of cortical excitation induced by periodontal stimulation in the model with experimental tooth movement」
  Kobayashi M (Dept Pharm, Nihon Univ Sch Dent)
• SS6-3「Oral pain and TRPV1 channel」
  Kido MA (Sec Anat Physiol, Saga Med Sch, Mol Cell Biol Oral Anat, Grad Sch Dent, Kyushu Univ)

Satellite symposium 7

August 24 (Wed) 14:20～16:00

• SS7-1「Type IX secretion system and gliding motility in Bacteroidetes phylum bacteria」
  Nakayama K (Division of Microbiology and Oral Infection, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences)
• SS7-2「The role of Porphyromonas gingivalis hydrogen sulfide in mouse inflammation」
  Shioya K (Dept Oral Microbiol, Matsumoto Dent Univ)
• SS7-3「Epidemiology and transmission of Porphyromonas gulae among dogs and owners」
  Haruka Sasaki (Div. Microbiol., Dept. Oral Sci., Kanagawa Dent. Univ.)
• SS7-4「Structural and Mechanistic Insights into a Distinct Type of Pilus」
  Shoji M (Nagasaki Univ Grad Sch Biomed Sci , Dept Microbiol Oral Infect, Japan)
• SS7-5「Osteoimmunology in Periodontal Disease」
  Masayuki Tsukasaki (Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo)

Satellite symposium 8

August 24 (Wed) 14:20～16:00

• SS8-1「Molecular basis of redox regulation for reactive persulfides」
  Takaaki Akaike (Dept Environ Health Sci Mol Toxicol, Tohoku Univ Grad Sch Med)
• SS8-2「Redox cross talk regulation between Nrf2 and eIF2-ATF4 pathway」
  Ken Itoh (Dept Stress Response Sci, Hirosaki Univ Grad Sch Med)
• SS8-3「Redox biology and dental disease –Periodontitis as vascular disease by alteration of redox balance-」
  Masaichi Lee (Yokosuka・Shonan・Disaster Health Emerg Res Center)
• SS8-4「8-Nitro-cGMP is a novel bone expansion factor」
  Miyamoto Y (Dept Biochem, Showa Univ Sch Dent)

Satellite symposium 9

August 24 (Wed)14：20～16：00

• SS9-1「The novel mechanism underlying Alzheimer's disease-like neuropathology and cognitive deficits following Porphyromonas gingivalis periodontal infection」
  Zhou Wu (Sect Aging Sci Pharmacol, OBT Res Center, Kyushu Univ Grad Sch Dent)
• SS9-2「The oscillation in the insular cortex implicated in taste-dependent feeding behavior」
  Hiroki Toyoda (Dept Neurosci Oral Physiol, Osaka Univ Grad Sch Dent)
• SS9-3「Modulation of taste sensitivity by orexigenic and anorexigenic factors: Effect of obesity.」
  Ryusuke Yoshida (Sect Oral Neurosci, Grad Sch Dent Sci, Kyushu Univ)
• SS9-4「Peripheral neural mechanisms underlying ectopic orofacial pain」
  Shinoda M (Dept Physiol, Nihon Univ Sch Dent)

Satellite symposium 10

August 24 (Wed) 14:20～16:00

• SS10-1「Analysis of in vivo bone marrow mesenchymal stem cells by fate mapping approach」
  Toshihide Mizoguchi (Inst for Oral Sci, Matsumoto Dent Univ)
• SS10-2「Regulation of developmental switching of salivary gland between "morphogenesis" and "differentiation"」
  Shinji Matsumoto (Dept of Mol Biol Biochem, The Univ of Osaka)
• SS10-3「Activated PDGFRα signaling in pericytes switches the cell fate」
  Iwayama (Dept Oral Anat Dev Biol, Osaka Univ Grad Sch Dent, Dept Periodontol, Osaka Univ Grad Sch Dent)
• SS10-4「Unveiling novel regulatory mechanisms of osteoclasts by combinatorial approaches of functional live-imaging and molecular omics」
  Ji-Won Lee (Ehime Univ, PROS, Div Bio-Imaging)
• SS10-5「The altered phtnotype of Tumor endothelial cells in tumor microenvironment」
  Kyoko Hida (Vascular Biol, Frontier Res Unit, Inst. for Genetic Med, Hokkaido Univ)

Satellite symposium 11

August 24 (Wed) 14:20～16;00

• SS11-1「Experience of personal identification of unidentified bodies using dental findings in the Great East Japan Earthquake 2011」
  Yumiko Ohbayashi (Dept Oral Maxillofac Surg, Fac Med, Kagawa Univ)
• SS11-2「Repeated problems of personal identification using dental findings in past disasters」
  Sakuma A (Dept Legal Med, Grad Sch Med, Chiba Univ)
• SS11-3「Why we need to become a specialist in forensic dentistry」
  Seiko Katsumura (Dept Forensic Med Dent ,Tsurumi Univ Sch Dent Med)
• SS11-4「Disaster victim identification by dental records : Response of dental society」
  Keiichi SASAKI (Tohoku Univ Grad Sch Dent, Div Adv Prosthet Dent)

Satellite symposium 12

August 24 (Wed) 14:20～16:00

• SS12-1「SCADA is Unique! 22 years history of the JDA / DENTSPLY Student Clinician Research Program」
  Tetsu Okumura (Dept Human-Comp Interface Design, Shizuoka Ins Sc Tech)
• SS12-2「Show the Sprit of Scientist !!! ~ What we found from SCRP~」
  Ryoki Kobayashi (Nihon Univ Sch Dent at Matsudo)
• SS12-3「Let's participate in SCRP! ~ SCADA and oral biology~」
  Joji Kusuyama (Dept Oral Biochem, Kagoshima Univ Grad Sch Med Dent Sci)

Satellite symposium 13

August 24 (Wed) 16:10～17:50

• SS13-1「Salivary glands: a unique and valuable system for oral biology and all biomedical science」
  Bruce J. Baum (Scientist Emeritus, Natl Inst Dent Craniofac Res, Bethesda, MD, USA)
• SS13-2「RNA interactions between tissues in fetal mouse salivary glands」
  Toru Hayashi (Dept Anat, Kitasato Univ Sch, Allied Health Sci)
• SS13-3「The Rho GTPase Cdc42 is required for maintenance of submandibular gland lumen.」
  Akiko Shitara (NCI, NIH)
• SS13-4「Physiological analysis of mouse salivary gland fluid secretion」
  Kondo Y (Div Oral Reconstr Rehabil, Kyushu Dent Univ)
• SS13-5「Tissue-autonomous development of the circadian rhythm in salivary glands」
  Uchida H (Dept Pathol, Sch Dent Med, Tsurumi Univ)

Satellite symposium 14

August 24 (Wed) 16:10～17:50

• SS14-1「The paradigm shift in taste research ~Identification and application of taste stem cells~」
  Ken Iwatsuki (Tokyo Univ Agric, Dept Nutr Sci Food Safety)
• SS14-2「Molecular mechanisms for the sweet-inducing effect of miraculin.」
  Keisuke Sanematsu (Sect Oral Neurosci, Grad Sch Dent, Kyushu Univ)
• SS14-3「Reduction of neurogenesis and olfactory function by impaired mastication and its recovery」
  Kashiwayanagi M (Dept Sensory Physiol, Asahikawa Med Univ)
• SS14-4「The intracortical integration mechanism for information of odor and taste」
  Mizoguchi N (Div Physiol, Dept Human Dev Foster, Meikai Univ Sch Dent)
• SS14-5「Evaluation of the masking of dimethyl sulfide odors by food derived volatiles through the use of trained odor sensor mice」
  Kazumi Osada (Div Physol, Dept Oral Boil, Sch Dent, Health Sci Univ Hokkaido)

Satellite symposium 15

August 24 (Wed) 16:10～17:50

• SS15-1「From understanding mechanisms of swallowing to treatment strategy of dysphagia」
  Makoto Inoue (Div Dysphagia Rehabilitation, Niigata Univ Grad Sch Med Dent Sci)
• SS15-2「Effects of histamine and serotonin on mesencephalic trigeminal neurons and jaw-closing motoneurons」
  Tomio Inoue (Dept Oral Physiol, Showa Univ Sch Dent)
• SS15-3「By what neuronal pathways do emotions affect mastication?」
  Yoshida A (Dept Oral Anat Neurobiol, Osaka Univ Grad Sch Dent)
• SS15-4「The pain pathway in the trigeminal nerve system, and the descending pain control by the cerebral motor cortex.」
  Tetsuya Goto (Dept Oral Anat & Cell Biol, Grad Sch Med & Dent Sci, Kagoshima Univ）
• SS15-5「Glial cell involvement in extraterritorial pain associated with trigeminal nerve injury」
  Koichi Iwata (Sch Dent, Nihon Univ)

Satellite symposium 16

August 24 (Wed) 16:10～17:50

• SS16-1「The importance and difficulty of the periodontal treatment」
  Akio MITANI (Dept Periodontol, Sch Dent, Aichi Gakuin Univ)
• SS16-2「Challenge for the novel therapeutics of periodontal regeneration」
  Yorimasa Ogata (Dept Periodontol, Nihon Univ Sch Dent at Matsudo)
• SS16-3「Periodontal tissue regeneration by transplantation of adipose tissue-derived multi-lineage progenitor cell」
  Takedachi M (Osaka Univ Grad Sch Dent, Dept Periodontol)
• SS16-4「Challenge for development of regenerative medicinal products using autologous cells.」
  Ken-ichiro Hata (Japan Tissue Engineering Co., Ltd)

Luncheon Seminar

• LS-1「Multi-modal applications of light microscopy for morphological and functional analyses of hard-tissue - From DIC (differential interference contrast) to innovative fluorescence microcopies-」
  AuthorTadahiro Iimura
• LS-2「Author workshop for young researchers supported by Elsevier: How to make a scientific paper including publishing ethics and image processing」
  Hayato Ohshima (Div Anat Cell Biol Hard Tissue, Niigata Univ Grad Sch Med Dent Sci, EIC of J Oral Biosci)
• LS 3-1「New insights into the taste reception (umami and salty)」
  Noriatsu Shigemura (Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Research and Development Center for Taste and Odor Sensing, Kyushu University)
• LS 3-2「Importance of umami taste sensitivity maintenance on elderly’s health with dentistry」
  Shizuko Satoh-Kuriwada (Division of Oral Diagnosisi, Tohoku University Graduate School of Dentistry)